منابع مشابه
In vitro synthesis of the E3 immunity protein directed by Col E3 plasmid deoxyribonucleic acid.
E3 colicinogenic cells are immune to colicin E3. A protein called "E3 immunity protein" was previously isolated from E3 colicinogenic cells and shown to prevent the E3-induced in vitro inactivation of ribosomes. We now show that the structural gene for E3 immunity protein resides on the Col E3 plasmid, a plasmid which is present in E3 colicinogenic cells and carries the structural gene for coli...
متن کاملImpact of substance P on cellular immunity.
Much evidence suggests a cross-talking between nerve fibers and the immunity system. The immunomodulation by substance P includes cell activation and proliferation of human cells, with cytokine and chemokine generation and release. Substance P was first isolated by Leeman et al. as an undecapeptide with important neurotransmitter-neuromodulator effects. In addition, substance P was shown to ind...
متن کاملE3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor–mediated antifungal innate immunity
Activation of various C-type lectin receptors (CLRs) initiates potent proinflammatory responses against various microbial infections. However, how activated CLRs are negatively regulated remains unknown. In this study, we report that activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk-dependent manner. Furthermore, we found that...
متن کاملThe Evolutionarily Conserved E3 Ubiquitin Ligase AtCHIP Contributes to Plant Immunity
Plants possess a sophisticated immune system to recognize and respond to microbial threats in their environment. The level of immune signaling must be tightly regulated so that immune responses can be quickly activated in the presence of pathogens, while avoiding autoimmunity. HSP90s, along with their diverse array of co-chaperones, forms chaperone complexes that have been shown to play both po...
متن کاملSalicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase.
Reversible modifications of target proteins by small ubiquitin-like modifier (SUMO) proteins are involved in many cellular processes in yeast and animals. Yet little is known about the function of sumoylation in plants. Here, we show that the SIZ1 gene, which encodes an Arabidopsis SUMO E3 ligase, regulates innate immunity. Mutant siz1 plants exhibit constitutive systemic-acquired resistance (S...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43050-0